The Iowa Lottery offers several draw games for those aiming to win big with rewards ranging from $1,000 to millions. The most an Iowan has ever won from playing the lottery was $343 million in 2018 off the Powerball.

Don’t miss out on the winnings. Here’s a look at Monday, Sept. 22, 2025, winning numbers for each game:

Winning Powerball numbers from Sept. 22 drawing

03-29-42-46-59, Powerball: 15, Power Play: 3

Check Powerball payouts and previous drawings here.

Winning Pick-3 numbers from Sept. 22 drawing

Midday: 5-4-5

Evening: 9-2-2

Check Pick-3 payouts and previous drawings here.

Winning Pick-4 numbers from Sept. 22 drawing

Midday: 8-0-7-7

Evening: 4-8-6-3

Check Pick-4 payouts and previous drawings here.

Winning Lucky For Life numbers from Sept. 22 drawing

06-09-15-42-43,

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