TEMPE, Ariz. – Arizona’s offense has had three chances in three games to close out a win this season and failed in all three instances.

The first two times, the Cardinals’ defense was there to save the day.

The third time, the team wasn’t as fortunate.

Arizona (2-1) lost its first game of the season on Sunday, falling 16-15 to San Francisco after a 35-yard field goal by Eddy Pineiro in the final seconds. Even worse for the long term, veteran running back James Conner is out for the season after suffering a foot injury in the loss.

“You hate that it happens, I feel terrible,” coach Jonathan Gannon said. “It’s tough to replace, but we have to. So that’s what we’ll do.”

The 30-year-old Conner has been the driving force behind the Cardinals running game over the past four-plus seasons,

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