Key Takeaways

A five-year-old dangerous social media challenge is alive and well

The Benadryl Challenge has continued to resurface since it first emerged on TikTok in 2020

At least one teen has died due to the challenge

FRIDAY, Sept. 26, 2025 (HealthDay News) — Teenagers and young adults are still harming themselves as part of a social media challenge that’s now five years old.

The Benadryl Challenge, which started in 2020 on TikTok, has spread to other social media platforms and is still being attempted by foolhardy young folks, researchers will report Sunday at an American Academy of Pediatrics meeting in Denver.

The challenge dares viewers to take heavy doses of over-the-counter allergy medicine containing the drug diphenhydramine. They must fight off the drowsiness caused by the

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