The San Francisco 49ers will try to stay undefeated when they host the Jacksonville Jaguars in a Week 4 NFL battle. The 49ers (3-0) survived an ugly 16-15 win against the Arizona Cardinals in Week 3, but added to their laundry list of injuries. They welcome a Jaguars team (2-1) coming off an equally rough 17-10 victory against the Houston Texans.

Kickoff from Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 3.5-point favorite in the latest Jaguars vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 47. The 49ers are -179 money line favorites (risk $179 to win $100), while the Jaguars are +147 underdogs. Before making any 49ers vs. Jaguars picks, make sure you check out the picks from the SportsLine Projection Model.

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