Early control of the NFC West will be on the line when the San Francisco 49ers take on the Los Angeles Rams on Thursday Night Football. San Francisco dropped a 26-21 decision to Jacksonville, while Los Angeles pulled out a 27-20 win over Indianapolis on Sunday. The Rams (3-1), who are 0-1 in the conference, are 2-0 on their home field this season. The 49ers (3-1), who are 3-0 in the conference, are 2-0 on the road. San Francisco quarterback Brock Purdy's status remains uncertain due to a toe injury.

Kickoff from SoFi Stadium in Inglewood, Calif., is set for 8:15 p.m. ET. The 49ers lead the all-time series 78-71-3, including wins in each of the last five meetings. The Rams are 3.5-point favorite in the latest 49ers vs. Rams odds, while the over/under for total points scored is set at 4

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