The Arizona Cardinals are dealing with a new setback. Running back Trey Benson will miss four games of the 2025 NFL season due to a knee injury. He was expected to return this week, but the team now adds another player to the injured list alongside James Conner.

Conner will miss the rest of the season due to a foot injury, marking a significant loss for the Cardinals. Adding to the list of absences in the position group is Benson, another painful setback for Arizona as the team prepares to face the Tennessee Titans on Sunday.

With two key players out for the Cardinals, questions arise about which remaining players can step up as primary weapons for Arizona’s offense. Quarterback Kyler Murray will have fewer options when throwing passes, making it essential to review the depth chart.

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