Amy Schumer isn’t one to hold back—and her Instagram videos are no exception. A few months ago, the 43-year-old comedian opened up about something many women silently struggle with: the frustrating mix of weight gain and low energy during perimenopause.

Filming casually from the driver’s seat of her car, Schumer told her followers she wanted to “keep it a hundred” about her health journey. She shared that she’d previously tried the well-known weight loss medication Wegovy a few years ago but had a rough experience.

“I was puking—I couldn’t handle it,” she said, adding that she wasn’t sure if the formula had changed since then. After that, she switched gears and booked a telehealth appointment, where she was prescribed hormonal support—specifically estrogen and progesterone—to help with s

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