Christian McCaffrey and the San Francisco 49ers face Puka Nacua and the Los Angeles Rams on Thursday Night Football in Week 5 of the NFL season at SoFi Stadium.

How to Watch 49ers vs Rams

Date: Thursday, October 2, 2025

Time: 8:15 PM ET

Channel: FOX (Local Broadcast Only) (Los Angeles) (San Francisco)

Stream: Fubo ( try for free )

The 49ers enter this game extremely short-handed and will have to try to find a way without their starting quarterback, top three wide receivers, and best defensive player. Most of the weight will fall on the shoulders of Christian McCaffrey, who has already taken on a massive workload this season. San Francisco's superstar running back has already gained over 530 yards from scrimmage this year on 100 touches. If the 49ers are to win this game, it is

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