The New England Patriots have their hands full with the Buffalo Bills in Week 5, even if their X-factor comes through . And here is why Milton Williams missing practice is such a bad sign for the AFC East showdown.

Williams is a key player for the Patriots on the defensive line, according to a post on X by Chris Brown.

“This is a noteworthy absence. Williams and fellow DT Christian Barmore have been a big interior presence in New England's run front thus far, where Pats are giving up just 77.5 rushing yards per game. #Bills #NEvsBUF”

How good is that run defense? The Patriots are tied with the Packers for No. 2 in the NFL.

Williams didn’t make it to the practice field Thursday, according to a post on X by Mike Reiss.

“DT Milton Williams (ankle), who was a limited participant i

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