Is Joe Mixon out for the season? When is Joe Mixon coming back? The latest Joe Mixon injury update and fantasy football outlook heading into Week 6 of 2025.

Houston Texans running back Joe Mixon (foot) has remained on the non-football injury/reserve list since the start of the regular season and has yet to return to practice.

While he could have returned to practice before Week 5, Mixon has yet to make any progress, further suggesting he is still several weeks away from a potential return.

Will Mixon play again this season? Should fantasy managers stash him on their bench? Let's dive in! Be sure to check all of our fantasy football rankings for 2025:

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