Patrick Mahomes suffers disaster as Kansas City Chiefs lose again following his major mistake against Jaguars

PATRICK Mahomes had a night to forget as the Kansas City Chiefs fell to defeat in Jacksonville.

The two-time MVP threw a 99-yard pick six as the Chiefs lost 31-28 against the Jaguars.

Mahomes completed 29 of 41 passes for 318 yards and a score during Monday Night Football.

But the game turned on a crucial interception late in the third quarter.

With the Chiefs in the RedZone and tied 14-14, Mahomes dropped into the pocket and threw an aggressive bullet pass towards wideout Juju Smith-Schuster.

His pass was brilliantly picked off on the goal line by Devin Lloyd, who set off on one of the best runs of the season so far.

Lloyd went the full 99 yards to the house, evading three Chiefs tackles and outpacing the chasing offensive line.

The pick six would change the game, with Jags QB