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Chargers RB depth chart: Who leads Los Angeles backfield after Omarion Hampton, Najee Harris injuries?

Just five games into the 2025 season, the Los Angeles Chargers are already down two running backs.

Najee Harris, an offseason signing, tore his Achilles in Week 3, ending his season. That injury opened the door for first-round rookie Omarion Hampton, who rushed for 128 yards in Week 4 against the New York Giants . But now, Hampton is also headed to the sidelines.

On Monday, Chargers head coach Jim Harbaugh announced that Hampton is being placed on injured reserve with an ankle injury. While the injury isn’t considered season-ending, Hampton will miss at least four games.

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