Five weeks of the NFL season have already blown by as the league prepares for another exciting Week 6 ahead. This is also a crucial time for fantasy managers as teams begin to mark their trajectory for the rest of the season and jockeying for playoff position. The running back may be the most volatile position in fantasy this season with all the depth chart changes and developments we've seen, so securing a solid RB duo will be important in winning any league.

First off, we'll get injury news out of the way – Los Angeles Chargers' rookie Omarion Hampton is heading towards IR with an ankle injury . Tampa Buccaneers' also sat during Week 5 and is expected to miss the Week 6 matchup against the San Francisco 49ers. Carolina Panthers' lead ball carrier is also trending towards missing a

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