When will George Kittle return and play? Will George Kittle be back again this season? Read the latest George Kittle injury updates and return date for Week 6 (2025).

After another productive season in San Francisco, George Kittle was one of the first tight ends off the board in fantasy football drafts in 2025. With the 49ers losing wide receiver Deebo Samuel Sr. (via trade to the Washington Commanders) and Brandon Aiyuk 's (knee) return date uncertain, Kittle had a clear runway to take off as the team's primary receiver.

Kittle looked ready to fill that role in Week 1, catching four balls and a touchdown in less than one half of work. Unfortunately, a hamstring strain in the second quarter ended Kittle's day and landed him on injured reserve, where he has remained since.

When wil

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