Players to watch — 49ers vs. Buccaneers: Christian McCaffrey, Vita Vea, Baker Mayfield, Kendrick Bourne, and Jake Tonges will take center stage Sunday as the San Francisco 49ers and Tampa Bay Buccaneers — both 4-1 and leading their divisions despite early injuries — square off in a matchup that could shape the NFC playoff race.

[caption id="attachment_250435" align="alignnone" width="300"] Sep 21, 2025; Tampa, Florida, USA; Tampa Bay Buccaneers defensive tackle Vita Vea (50) recovers the fumble against the New York Jets during the second quarter at Raymond James Stadium. [/caption]

Players to Watch: 49ers vs. Buccaneers - Week 6

Top Players

All-Pro running back Christian McCaffrey is off to another stellar start to the season. Through five games, he has run the ball 91 times for 282 ya

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