Two people involved in venture capital life science start-ups write hopefully about our city’s future (“ Baltimore is overrun with opportunity, not crime ,” Oct. 10). As someone who hosted a first biotech “kitchen cabinet” dinner of brainstorming government, investor and university science leaders in the mid-1980s, I could not be more supportive.

But without trying to sound wistful, the endemic entrepreneurial magic that at that time spawned Silicon Valley, Boston, Research Triangle and Austin has still not arisen hereabouts in the corporate, civic and popular mentality. We have a surfeit of science, but do we have a tipping point of brash, bold and daring mentality to speed brainpower into the marketplace? I know of some notable examples but do not yet see a critical mass. As your writ

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