TAMPA, Fla. -- The San Francisco 49ers took another significant injury hit Sunday when linebacker Fred Warner departed in the first quarter with a right ankle injury.

The 49ers almost immediately ruled out a possible return for Warner after he was taken to the locker room via cart.

Warner injured his ankle with just under eight minutes left in the first quarter. On first-and-10 at Tampa Bay's 36, running back Rachaad White ran off left tackle for a gain of 10 yards. Warner seemed to corral White but as he attempted to take him down, Niners safety Ji'Ayir Brown rolled into the back of Warner's right ankle.

Brown reacted quickly, knowing that Warner might be seriously hurt and teammates quickly put their hands on their heads and dropped to a knee as they watched San Francisco's me

See Full Page