Scientists may have found the key to weakening prostate cancer cells and boosting treatment effectiveness

A groundbreaking international study has uncovered a critical vulnerability in prostate cancer cells, offering a promising avenue for more effective treatments. Led by scientists from Flinders University, Australia, in collaboration with South China University of Technology, the research identifies two key enzymes, PDIA1 and PDIA5, that play a vital role in maintaining cancer cell survival and treatment resistance. These enzymes act as molecular chaperones for the androgen receptor (AR), a protein that drives tumour growth. By targeting PDIA1 and PDIA5, researchers were able to destabilise the AR, trigger cancer cell death, and enhance the effectiveness of existing drugs like enzalutamide. This discovery could pave the way for new combination therapies against advanced and resistant prost