When scanning which games to make Week 8 college football picks on, one's eyes will gravitate towards the SEC. It features three ranked matchups, with all six of the competing squads ranked 17th or better. There's Ole Miss vs. Georgia (-7.5), Alabama (-8.5) vs. Tennessee and Vanderbilt (-2.5) vs. LSU. Outside of the SEC, another intriguing game to make Week 8 college football bets on is one of the most storied series in the sport as USC vs. Notre Dame has the Irish favored by 9.5 points in South Bend, Ind.

Meanwhile, the Big Ten has eight conference games, and while it doesn't featured any ranked matchups, it does possess two of the biggest Week 8 college football spreads. The top-ranked Buckeyes are 25.5-point favorites over Wisconsin, while No. 3 Indiana is favored by 27 points over Mic

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