It's a milestone in TV history.

ABC's "Grey's Anatomy" - the longest-running medical drama in the U.S. - is celebrating its 450th episode, and On The Red Carpet was on-site at the happy occasion where cast members shared their thoughts about being a part of the historic moment.

"I'm completely buzzing. I mean this show is historic every day just because of the people I get to work with, the stories we tell, how long we've been telling them. And I feel the reverence of that every day," star Alexis Floyd says.

Jason George, who's been a part of the show since season 6 (now on season 22) and starred in the spinoff "Station 19," explains, "The show's as good as it's ever been. The feels are there. The comedy that comes in - the way it gets you laughing and then crying in the middle of a lau

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