Anthony Santander 's postseason for the Toronto Blue Jays ended Thursday, with Major League Baseball approving a roster substitution for the ailing outfielder.

Santander has been battling a back injury that led him to being scratched from Game 2 of the AL Championship Series against the Seattle Mariners . He started in right field in Game 3, but was replaced after two at-bats in an eventual 13-4 Toronto road win that cut its series deficit to 2-1.

MLB's announcement came a little over an hour before Game 4 on Thursday night in Seattle.

The league said Dr. Gary Green, its medical director, confirmed Santander's injury "after a full review of the medical information." He was replaced by Joey Loperfido on Toronto's roster.

By rule, Santander can't return for the Mariners series or

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