The Louisville Cardinals (4-1, 1-1 ACC) and the No. 2 Miami Hurricanes (5-0, 1-0) meet Friday at Hard Rock Stadium in Miami Gardens, Florida. Kickoff is scheduled for 7 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA football odds around the Louisville vs. Miami odds and make our expert college football picks and predictions for the best bets.

The Hurricanes lead the all-time series 12-4, including an absolutely wild 52-45 win in Louisville last season on Oct. 19, 2024. Miami covered a 4-point favorites as the Over (61) easily cashed. The Canes have won and covered 3 of the past 4 meetings since 2019, with the Over cashing in each of the meetings.

Louisville suffered a 30-27 overtime loss against the Virginia Cavaliers last time out, losing outright as a 6.5-point fa

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