Oklahoma Sooners quarterback John Mateer (10) rushes against the Texas Longhorns in the first half of the Red River Rivalry game at the Cotton Bowl Stadium in Dallas, Texas.

The Oklahoma Sooners (5-1, 1-1 SEC) visit the South Carolina Gamecocks (3-3, 1-3) in a Saturday SEC contest. Kickoff at Williams-Brice Stadium in Columbia, South Carolina, is at 12:45 p.m. ET (SEC Network). Let's analyze BetMGM Sportsbook's NCAA football odds around the Oklahoma vs. South Carolina odds and make our expert college football picks and predictions for the best bets.

No. 13 Oklahoma dropped a rivalry battle last Saturday, losing to the No. 17 Texas Longhorns 23-6. OU turned the pigskin over three times and filed a season-low 258 yards against the Longhorns. A Sooners team that cranked out 472.7 yards per game over its first 3 games has averaged just 305.3 YPG since.

The Gamecocks dropped their third game in their last 4 with a 20-10 loss at the LSU Tigers last Saturday. South Carolina -- which drilled Oklahoma 35-9 in the first OU-USC meeting last Oct. 19 -- was held to just 317 yards, and that included a 72-yard Matt Fuller TD run late in the first quarter.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Watch NCAA football on Fubo!

Oklahoma at South Carolina odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 3:42 p.m. ET.

  • Moneyline (ML): Oklahoma -210 (bet $210 to win $100) | South Carolina +170 (bet $100 to win $170)
  • Against the spread (ATS): Oklahoma -4.5 (-115) | South Carolina +4.5 (-105)
  • Over/Under (O/U): 43.5 (O: -105 | U: -115)

Play our free daily Pick’em Challenge and win! Play now!

Oklahoma at South Carolina picks and predictions

Prediction

Oklahoma 26, South Carolina 16

Moneyline

No interest; PASS.

Against the spread

South Carolina is 1-3-1 ATS in its last 5 home games when lined as a 4-to-6-point underdog.

Looking for a stingy, talented, havoc-inducing Oklahoma defense to punch back after last week's loss to Texas. And the Gamecocks are iffy on offense, most especially in staying on schedule when putting the ball in the air. Its a revenge spot for the Sooners after last year's embarrassing home loss to South Carolina. In that game, OU outgained USC 291 yards to 254, but the Sooners were undone by a minus-4 in turnovers. The Gamecocks filed a scoop-and-score and a Pick-6, and they had 2 short-field scoring drives.

And turnovers have chipped away at the 2025 Sooners: Oklahoma has averaged 29.2 points per game and allowed 9.8 PPG despite being a minus-7 in turnovers.

The success-rate differential in this game make a double-digit OU win likely enough. Look for an angry, motivated Sooner squad to take care of business. BET OKLAHOMA -4.5 (-115).

Over/Under

The Under has hit in 7 straight OU games and in 6 of USC's last 8. The last 3 Sooners game filed Under with double-digit margins to spare.

Both sides have excelled in getting red-zone stops. In percentage of TDs allowed on defensive red-zone stands, Oklahoma and South Carolina rank first and second, respectively, in the SEC.

The pace -- likely quick -- swings things the other way, but by a slim margin, the UNDER 43.5 (-115) is the value play in this one.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Auburn / Clemson / Colorado / Duke / Florida / Florida State / Georgia / Iowa / Kentucky / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Tennessee / Texas / Texas A&M / UCLA / USC / Washington / Wisconsin / College Sports Wire / High School / Recruiting

This article originally appeared on Sportsbook Wire: Oklahoma Sooners at South Carolina Gamecocks odds, picks and predictions

Reporting by Skip Snow, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect