Indiana Hoosiers coach Curt Cignetti looks up at the scoreboard during an NCAA football game against the Oregon Ducks at Autzen Stadium in Eugene, Oregon.

The Michigan State Spartans (3-3, 0-3 Big Ten) and the No. 3 Indiana Hoosiers (6-0, 3-0) meet Saturday at Memorial Stadium in Bloomington, Indiana. Kickoff is scheduled for 3:30 p.m. ET (Peacock). Let's analyze BetMGM Sportsbook's NCAA football odds around the Michigan State vs. Indiana odds and make our expert college football picks and predictions for the best bets.

The Spartans lead the all-time series 50-19-2, although the Hoosiers won last season's matchup 47-10 as 7.5-point favorites in East Lansing as the Over (53.5) cashed. The road team has won the past 5 meetings since 2020, while the road team has covered 7 in a row in this series. The Under is 3-1 in the past 4 meetings in Bloomington.

Michigan State was buried 38-13 at home against UCLA last Saturday despite being favored by 7 points. After a 3-0 SU start, the Spartans are 0-3 SU inside the conference, although they're 2-1 against the spread (ATS). The Under (52) cashed against UCLA, but the Over is 4-1 in the past 5 games.

Spartans QB Aidan Chiles hasn't looked 100 percent in recent games, and he was just 8-of-17 for 66 yards with a rushing TD against UCLA. Chiles is nursing an undisclosed injury. QB Alessio Milivojevic completed 8-of-18 for 100 yards, 1 TD and no picks, splitting reps with Chiles.

Indiana stunned then-No. 2 Oregon at Autzen Stadium in Eugene last Saturday, winning 30-20 as a 7-point underdog with the Under (51) sneaking in. QB Fernando Mendoza completed 20-of-31 passes for 215 yards, 1 TD and 1 INT, while RB Roman Hemby rushed for 70 yards and 2 scores. WR Elijah Sarratt pulled down 8 receptions for 121 yards and a TD.

The Hoosiers are 4-1 ATS in the past 5 games, while the Under has cashed in back-to-back outings after 3 consecutive Overs. With No. 2 Miami losing at home Friday night to Louisville, Indiana has a chance to climb even higher than its current No. 3 ranking -- its highest ranking in program history.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Michigan State at Indiana odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:23 a.m. ET.

  • Moneyline (ML): Michigan State +1750 (bet $100 to win $1,750) | Indiana -10000 (bet $10,000 to win $100)
  • Against the spread: Michigan State +27.5 (-110) | Indiana -27.5 (-110)
  • Over/Under (O/U): 49.5 (O: -105 | U: -115)

Michigan State at Indiana picks and predictions

Prediction

Indiana 45, Michigan State 13

Moneyline

It shouldn't even need to be said, but Indiana (-10000) will cost 100 times the potential return. In other words, that's a $100 risk for just $1 in profit. Even if you tossed IU into a 10-team parlay and hit it, including the Hoosiers would take so much value out of your ticket.

PASS and look to the spread instead.

Against the spread

INDIANA -27.5 (-110) is looking to snap a 5-game win and 7-game cover streaks by the road team in this series. It's hard to wrap your mind around anything but a convincing Indiana win. The things to worry about are a possible hangover after the big win at Oregon and a sluggish start. Even then, Indiana has way more talent on the field than the disjointed Spartans.

Over/Under

OVER 49.5 (-105) is the play. It wouldn't be surprising if Indiana hits the Over all on its own. The Hoosiers are top 10 in the nation with 502.8 total yards (ranking eighth), 241.7 rushing yards (ninth) and 44.8 points per game (fourth). However, the defense ranks fourth in points allowed at 11.3 PPG. Plus, the Over is 4-1 in the past 5 games for Michigan State, allowing at least 38 points in 4 of the past 5 games.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Michigan State Spartans at Indiana Hoosiers odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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