Parkinson's Discovery Suggests We May Have an FDA-Approved Treatment Already

Researchers have discovered how a surface protein on brain cells, called Aplp1, can play a role in spreading material responsible for Parkinson's disease from cell to cell in the brain.

Promisingly, an FDA-approved cancer drug that targets another protein – Lag3 – which interacts with Aplp1 – was found to block this process in mice. This suggests a potential treatment for Parkinson's may already exist.

In a paper published last year , an international team of scientists detailed how the two proteins work together to help toxic clumps of alpha-synuclein protein get into brain cells.

"Now that we know how Aplp1 and Lag3 interact, we have a new way of understanding how alpha-synuclein contributes to the disease progression of Parkinson's disease," neuroscientist Xiaobo Mao from