New book by William J. Walsh, Ph.D., reveals how ion channel gene weaknesses and DNA damage drive the mania–depression cycle.

NAPERVILLE, Ill. , Oct. 20, 2025 /PRNewswire/ -- The Walsh Research Institute (WRI) announces a major scientific breakthrough in understanding bipolar disorder, revealed in The Essence of Bipolar Disorder by William J. Walsh, Ph.D. (Skyhorse Publishing, 2025). Based upon recent advances in neuroscience and genetics, this information has led to an explanation for mania/depression switching, new treatment opportunities, and an advanced theory of bipolar disorder.

More than nine million Americans are diagnosed with bipolar disorder, a leading cause of suicide, unemployment, and loss of human potential. For decades, its biological origins have remained elus

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