After the defending NBA champion Oklahoma City Thunder and three fellow Western Conference contenders opened the season on Tuesday, most of the rest of the league gets its turn Wednesday night.

New eras and vibes abound in arenas and locker rooms.

As for the betting analysis, it’s business as usual.

Let’s see how these picks stack up on the Association’s first busy night of 2025-26.

CLEVELAND CAVALIERS at NEW YORK KNICKS, 7 p.m.

Many view these high-scoring attacks as the top two contenders in the Eastern Conference.

With a trio of Top 20 scorers from last season involved, this opener from Madison Square Garden should at least pack plenty of points.

New York’s Jalen Brunson (26 points) and Karl-Anthony Towns (24.4) will aim to outdo Cleveland’s Donovan Mitchell (24.4), who has his

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