On Day 2 of the regular season game of the 2025-26 NBA season, the matchup between the New York Knicks and the Cleveland Cavaliers will go live on October 22, 2025, with kickoff at 7:00 pm ET from the Madison Square Garden in New York. The Knicks will play host to the Cavs for their first face-off this season, and both teams are looking to start their campaign strong. The Knicks have home ground advantage over their opposition, but the Cavs who finished top of the table during the regular season last time will also play to their advantage. The New York Knicks ended as the 3rd seed in the Eastern Conference at the end of the regular season last time, but have a pretty depleted roster with a lot of players out injured, including Mitchell Robinson and Karl-Anthony Towns. With half the r
New York Knicks vs. Cleveland Cavaliers (10-22-2025) Regular season game injury report: Who's playing, who's out, and more

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