The Iowa Lottery offers several draw games for those aiming to win big with rewards ranging from $1,000 to millions. The most an Iowan has ever won from playing the lottery was $343 million in 2018 off the Powerball.

Don’t miss out on the winnings. Here’s a look at Wednesday, Oct. 22, 2025, winning numbers for each game:

Winning Powerball numbers from Oct. 22 drawing

18-37-52-54-60, Powerball: 12, Power Play: 2

Check Powerball payouts and previous drawings here.

Winning Pick-3 numbers from Oct. 22 drawing

Midday: 6-0-6

Evening: 4-7-5

Check Pick-3 payouts and previous drawings here.

Winning Pick-4 numbers from Oct. 22 drawing

Midday: 9-2-8-5

Evening: 4-1-6-7

Check Pick-4 payouts and previous drawings here.

Winning Lucky For Life numbers from Oct. 22 drawing

01-20-30-37-46, L

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