The North Texas Mean Green will look to stay in the American Conference title chase when they battle the Charlotte 49ers in a key matchup on Friday night. North Texas is coming off a 55-17 win over UTSA, while Charlotte dropped a 49-14 decision to Temple in Week 8. The Mean Green (6-1, 2-1 American), who are tied for fourth in the conference, are 2-0 on the road this season. The 49ers (1-6, 0-4 American), who have lost four in a row, are 1-3 on their home field in 2025.

Kickoff from Jerry Richardson Stadium in Charlotte, N.C., is at 7 p.m. ET. Charlotte is 2-0 all-time against North Texas. The Mean Green are 25.5-point favorites in the latest North Texas vs. Charlotte odds, while the over/under for total points scored is 60.5. Before making any North Texas vs. Charlotte picks, check

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