The UFC heavyweight championship will be on the line on Saturday when champion Tom Aspinall takes on No. 1 contender Ciryl Gane at UFC 321: Aspinall vs. Gane. Aspinall first won the interim UFC heavyweight championship with a knockout of Sergei Pavlovich at UFC 295 in November 2023, and defended the title with a knockout of Curtis Blaydes at UFC 304 in July 2024. He was promoted to undisputed champion on June 21, 2025. Gane is coming off a split decision win over Alexander Volkov at UFC 310 last December. The main card from Etihad Arena at Yas Island/Yas West, United Arab Emirates is set to begin at 2 p.m. ET, with the prelims beginning at 10 a.m. ET.

Aspinall enters as the favorite at -345 (risk $345 to win $100), while Gane is the underdog at +275 in the latest UFC 321 odds at DraftKing

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