For the third consecutive year, the New Orleans Saints and Los Angeles Rams will meet during the regular season. These two franchises have taken different paths since their controversial 2019 NFC Championship Game, with the Saints struggling to find a new franchise quarterback while the Rams look to add another Super Bowl under Sean McVay and Matthew Stafford. New Orleans is going to be in contention for the No. 1 pick in the 2026 NFL Draft, while Los Angeles is building towards another playoff berth. According to the latest Saints vs. Rams odds, Los Angeles is favored by 14 points, while the over/under for total points scored is 43.5.

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