(NEXSTAR) – A UPS plane with three crew members aboard crashed in Louisville, Kentucky shortly after takeoff Tuesday evening, causing an extensive fire and taking the lives of at least three people, officials confirmed.

Gov. Andy Beshear said at least 11 people were injured and some had "very significant injuries." He said he believed the number of fatalities and injuries would "get larger" as the investigation continued.

The crash happened around 5:15 p.m., shortly after UPS Flight 2976 took off from Louisville Muhammad Ali International Airport (SDF), an FAA spokesperson told Nexstar. The flight was bound for Honolulu.

The plane's cargo didn't contain anything hazardous, but was full of 220,000 pounds of jet fuel. Photos from the scene showed towering flames and a cloud of black smoke

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