A cargo plane has crashed on takeoff in the US, sending flames shooting into the sky. Photo: AP PHOTO

A UPS cargo plane has crashed and exploded in a massive fireball while taking off from the company's global aviation hub in Louisville, Kentucky, killing at least four people and injuring 11.

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The plane, carrying three people, was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport when it crashed.

Video showed flames on the plane's left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a

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