LOUISVILLE, Ky. – A UPS cargo plane crashed and exploded in a massive fireball Tuesday while taking off from the company’s global aviation hub in Louisville, Kentucky, killing at least seven people and injuring 11, authorities said.

The plane crashed about 5:15 p.m. as it was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport.

Video showed flames on the plane’s left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball. Video also revealed portions of a building’s shredded roof next to the end of the runway.

The death toll had risen to at least seven Tuesday night, and four of those killed were not on the plane, officials said.

Among the 11 who were hurt, some had “very significa

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