Scientists have explored creatine’s potential to alleviate depressive symptoms, presenting a comprehensive systematic review and meta-analysis published recently in the British Journal of Nutrition. Depression affects nearly 280 million people globally, with many facing inadequate treatment options that are often slow to take effect and burdened by adverse effects. Creatine, widely known for its role in enhancing physical performance, has drawn interest for its central involvement in brain energy metabolism—areas disrupted in depression.

Creatine supports brain energy homeostasis and neurotransmitter regulation, with lower brain creatine levels linked to depression and treatment resistance. Dietary creatine intake correlates inversely with depression prevalence, hinting at its therapeut

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