The Arizona Cardinals (3-5) visit the Seattle Seahawks (6-2) Sunday in Week 10. Kickoff from Lumen Field in Seattle, Washington, is at 4:05 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Cardinals vs. Seahawks odds and make our expert NFL picks and predictions for the best bets.
The Cardinals snapped a 5-game losing streak Monday, beating the Dallas Cowboys 27-17 as 3-point road underdogs with the Under (53.5) cashing. QB Jacoby Brissett threw 2 TD passes and rushed for another in his third start. He will be the starter moving forward as Kyler Murray was placed on injured reserve after missing 3 games with a foot sprain.
The Seahawks have won 3 games in a row and are coming off a 38-14 Sunday night win over the Washington Commanders as 3-point road favorites. The Over (47) cashed. QB Sam Darnold had more TD passes (4) than incompletions (3).
The Seahawks beat the Cardinals 23-20 in Week 4 in Arizona on a last-second field goal, covering the 1.5-point spread as favorites with the Under (44) cashing. Seattle leads the all-time series 30-22-1 and has won 8 straight meetings.
Watch the NFL on Fubo!
Cardinals at Seahawks odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:46 a.m. ET.
- Moneyline (ML): Cardinals +260 (bet $100 to win $260) | Seahawks -325 (bet $325 to win $100)
- Against the spread (ATS): Cardinals +7 (-115) | Seahawks -7 (-105)
- Over/Under (O/U): 45.5 (O: -110 | U: -110)
Cardinals at Seahawks key injuries
Cardinals
- S Kitan Crawford (ankle) questionable
- OL Will Hernandez (knee) questionable
- CB Will Johnson (back, hip) out
- CB Max Melton (concussion) out
- LB BJ Ojulari (knee) out
- LB Mack Wilson (ribs) out
Seahawks
- TE A.J. Barner (calf) questionable
- WR Jake Bobo (calf) out
- OL Christian Haynes (pec) out
- WR Tory Horton (groin, shin) doubtful
- CB Josh Jobe (concussion) out
- LB Ernest Jones (knee) doubtful
- WR Cooper Kupp (hamstring, heel) questionable
Cardinals at Seahawks and predictions
Prediction
Seahawks 31, Cardinals 13
Moneyline
The Seahawks have beaten the Cardinals in 8 straight meetings. They have averaged 30.0 points over their last 4 games and have not allowed more than 19 in their last 3, all wins.
The Cardinals are 1-5 in their last 6 games. While Brissett has the offense doing better, as the Cardinals have averaged 25.7 points in his 3 starts, he has taken 13 sacks and been hit 35 times. Seattle's pass rush, which has 27 sacks and 64 hits, will be too much.
The Seahawks win, but the spread is the better bet.
PASS.
Against the spread
The Seahawks are 6-1-1 ATS in their 8-game winning streak against the Cardinals. The Cardinals have covered the spread in all 3 of Brissett's starts while the Seahawks have covered the spread in all 6 of their wins.
BET SEAHAWKS -7 (-105).
Over/Under
In 3 of the Seahawks' last 4 games and in 5 of their last 7, the Over has cashed. The Over is 3-1 in the Cardinals' last 4 games.
BET OVER 45.5 (-110).
WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle has been turning players like you into winners for over 25 years. This season, it's your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now!
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
Follow SportsbookWire on Twitter/X and like us on Facebook.
Access more NFL coverage:
TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
This article originally appeared on Sportsbook Wire: Arizona Cardinals at Seattle Seahawks odds, picks and predictions
Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire
USA TODAY Network via Reuters Connect

USA TODAY National
WTOP Sports
Associated Press Top News
NFL Seattle Seahawks
The Columbian Sports
NFL Cleveland Browns
Orlando Sentinel Sports
NFL Dallas Cowboys
Democrat and Chronicle
America News