San Francisco 49ers running back Christian McCaffrey, middle, is tackled by Los Angeles Rams players. AP New York Post may be compensated and/or receive an affiliate commission if you click or buy through our links. Featured pricing is subject to change.

The Rams and 49ers will go head-to-head in Week 10 in their second meeting of the season. Both teams have been on a roll this season and are looking to separate themselves in a crowded NFC West.

The Rams (6-2) have the better record with just two losses, but the Niners (6-3) have the head-to-head tiebreaker by virtue of their overtime win in Week 5.

The Rams are 5.5-point favorites in this game with the Over/Under listed at 49.5 points.

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