The San Francisco 49ers enter a make-or-break stretch over the next four weeks. How they perform against the Carolina Panthers, Arizona Cardinals, Tennessee Titans, and Cleveland Browns will determine whether they remain legitimate postseason contenders or just pretenders. Since starting the season with three straight wins, the injury-depleted 49ers have alternated victories and losses, sitting at 6–4 through ten weeks of the 2025 campaign.

49ers Make-or-Break Stretch Could Decide Playoff Fate

[caption id="attachment_254167" align="aligncenter" width="640"] Nov 9, 2025; Santa Clara, California, USA; Los Angeles Rams tight end Terrance Ferguson (18) drops a pass while being defended by San Francisco 49ers linebacker Luke Gifford (57) during the fourth quarter at Levi's Stadium. Mandatory

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