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Wednesday’s 12-game NBA DFS slate tips off at 7 p.m. ET and offers a mix of competitive contests and potential blowouts to navigate. The Cleveland Cavaliers-Miami Heat matchup features the highest projected total of the night at 238.5, while the Denver Nuggets-Los Angeles Clippers game has the lowest at 226.5.

The only game with a double-digit spread is the Washington Wizards-Houston Rockets matchup, which sits at Houston -16.5, followed by the Portland Trail Blazers-New Orleans Pelicans contest, with Portland favored by 7.5 points. With several variables in play — including wide spreads, injury situations and teams on the second leg of back-to-backs — lineup differentiation and identifying favorable game environments will be key to gaining an edge.

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