The 2025-26 college basketball schedule continues on Wednesday, Nov. 12, with over 50 games involving Division I teams. Two contests feature ranked teams in action with No. 1 Houston vs. Oakland (+28.5) and No. 12 Tennessee vs. North Florida (+40.5). The Cougars will play their first game as the top-ranked team after leapfrogging Purdue in the AP Poll, while the Volunteers, who are amongst the biggest favorites per the college basketball odds, will take on the Ospreys for the first time ever.

Other college basketball lines of note include Minnesota vs. Missouri (-6.5), Marquette vs. Little Rock (+20.5) and Oregon vs. South Dakota State (+16.5). With just two games under most teams' belts and little data to go off, what are the Wednesday college basketball best bets t

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