We’ve got some big-time games with College Football Playoff implications in Week 12 on the college football calendar. Let’s make some betting predictions.

Each week, I’ll be sharing picks against the spread . Lines are courtesy of FanDuel as of Wednesday afternoon.

After a 4-1 showing in Week 10, we were 3-2 last week, bringing the season total to 27-29-1.

Clemson at Louisville (-2.5)

Friday, 7:30 p.m., ESPN

We start off with an intriguing Friday tilt. The Cardinals, not Clemson, are in the ACC title and CFP mix despite falling at Cal in overtime last weekend. The Tigers handled Florida State at home and are 4-5, pushing for bowl eligibility. But this is Clemson’s first road game in a month. I lean toward Louisville in a bounce-back spot with more to play for. The pick: Louisv

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