The Clemson Tigers (4-5, 3-4 ACC) and Louisville Cardinals (7-2, 4-2) clash in Atlantic Coast Conference action Friday. The opening kickoff at L&N Federal Credit Union Stadium in Louisville, Kentucky, will be at 7:30 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NCAA football odds around the Clemson vs. Louisville odds and make our expert college football picks and predictions for the best bets.

Clemson had lost 2 straight games with a bye week sandwiched in, so when it defeated the 1.5-point underdog Florida State Seminoles 24-10 (Under 57) last Saturday the victory marked the Tigers' first since Oct. 18. Clemson's 5 losses mark its most since coach Dabo Swinney ' s first season (2009).

The No. 21 Cardinals were upset by +18.5 Cal last week. A 29-26 (Over 48.5) los

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