A pair of ranked teams are in action during the Friday college football schedule, as No. 20 Louisville hosts Clemson at 7:30 p.m. ET while No. 8 Oregon faces Minnesota at 9 p.m. ET. The Cardinals had their three-game winning streak snapped in an overtime loss to California last week, while the Tigers ended a two-game skid with a 24-10 win over Florida State. Louisville is a 2.5-point favorite in the Week 12 college football odds, but SportsLine's proven computer model prefers the Over (51.5) in that matchup.

Oregon is riding a three-game winning streak and is a 25.5-point favorite against Minnesota on Friday night. However, the model is rolling with the Golden Gophers to cover in its Friday college football best bets for online sports betting .

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