The Oregonian/OregonLive sports staff is here with picks for Week 12’s high-stakes slate of the 2025 college football season.

No. 8 Oregon hosts Minnesota as a heavy favorite on Friday night, though the Golden Gophers’ rock-solid defense has the potential to cause some issues for the Ducks. Meanwhile, the Oregon State Beavers hit the road for what’s expected to be a close battle against Tulsa on Saturday.

Saturday also brings a handful of top-25 matchups that could reshape this year’s playoffs, including SEC showdowns between No. 11 Oklahoma and No. 4 Alabama and between No. 10 Texas and No. 5 Georgia. Plus, No. 17 USC hosts No. 21 Iowa, and No. 9 Notre Dame visits No. 22 Pittsburgh.

Check out our game picks below.

Season totals

Straight up

Sean Meagher : 102-38 (8-4 last w

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