The 15th-ranked Louisville Cardinals look to keep their conference championship hopes alive when they battle the Clemson Tigers in a key ACC matchup on Friday. Clemson is coming off a 24-10 win over Florida State, while Louisville looks to rebound from a 29-26 loss to California last Saturday. The Tigers (4-5, 3-4 ACC), who are 10th in the conference standings, are 2-1 on the road this season. The Cardinals (7-2, 4-2 ACC), who are sixth in the league, are 4-2 on their home field in 2025.

Kickoff from L&N Federal Credit Union Stadium in Louisville, Ky., is at 7:30 p.m. ET. The Cardinals are 2.5-point favorites in the latest Clemson vs. Louisville odds, while the over/under for total points scored is 50.5 via SportsLine consensus. Before making any Louisville vs. Clemson picks, check

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