Brock Purdy passed for 200 yards and three touchdowns in his first game since Sept. 28, Christian McCaffrey scored three touchdowns and the San Francisco 49ers beat the error-prone Arizona Cardinals 41-22 on Sunday in Glendale, Ariz.

Purdy completed 19 of 26 passes without an interception in his return from a turf toe injury suffered in the season opener and aggravated in a 26-21 loss to Jacksonville in Week 4.

McCaffrey scored the 49ers' first and last touchdowns, on 1- and 4- yards runs, and added a 9-yard scoring reception. He had 81 yards rushing and 121 yards from scrimmage.

Arizona quarterback Jacoby Brissett completed an NFL regular season-record 47 passes in 57 attempts for a career-high 452 yards, with two touchdowns and two picks. His streak of 166 consecutive passes without a

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