Nov 4, 2025; Charlotte, North Carolina, USA; Duke Blue Devils head coach Jon Scheyer watches the play against the Texas Longhorns during the first half of the Dick Vitale’s Invitational game at Spectrum Center. Mandatory Credit: Cory Knowlton-Imagn Images

As the New York City lights get brighter into the evening, the State Farm Champions Classic continues with its second headlining matchup of the evening when two of the sport's premier programs tip off.

In the second game of the event, the Duke Blue Devils (4-0) go at it with the Kansas Jayhawks (3-1) in a matchup of two programs with as much history as anyone in college basketball.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of DraftKings.

Stream Duke vs. Kansas

Duke vs. Kansas game odds

All college basketball odds via DraftKings

  • Spread: Duke -7.5 (-110), Kansas (+7.5 (-110)
  • Money Line: Duke -305, Kansas +245
  • Over-Under: Over 150.5 (-110), Under 150.5 (-110)

Duke vs. Kansas prediction, pick:

Duke has things starting to roll lately. The Blue Devils are reloading year after year, and through four games, they look the part. Aside from the season-opening win against Texas, Duke has hung up more than 95 points each game. More impressively, no team has scored more than 62 on them. They are playing phenomenal defense.

Kansas, whose only loss came to Duke's rival, North Carolina, is still searching for that offensive explosion. The Jayhawks scored 95 against Green Bay, but have averaged just 75.7 points per game otherwise.

Cameron Boozer is among the best freshmen in the country, averaging 22.5 points and 10.3 rebounds so far on the season for Duke. Kansas forward Flory Bidunga and Bryson Tiller will have their hands full trying to contain him.

Duke can score enough to win ugly if they have to, and they may just do that in this one. As fun and talented as the Blue Devils have been on offense, the defense shines under the Madison Square Garden lights to get a strong victory.

Prediction: Duke 82, Kansas 70

Best Bet: Duke -8.5

Duke vs. Kansas start time, streaming:

Time: 9 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Duke vs. Kansas: College basketball betting odds, prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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