Perennial college basketball powers meet up in one of the earliest tips on the Tuesday college basketball schedule as the No. 12 Kentucky Wildcats face the No. 17 Michigan State Spartans in the 2025 Champions Classic. The Spartans are 3-0 with a win over John Calipari and Arkansas highlighting the season thus far. Kentucky is 3-1 as the Wildcats lost at Louisville a week ago.

Tipoff from Madison Square Garden in New York is at 6:30 p.m. ET. The Wildcats are 4.5-point favorites in the latest Kentucky vs. Michigan State odds, while the over/under is 152.5. Before making any Michigan State vs. Kentucky picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model .

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