Buffalo Bills quarterback Josh Allen celebrates after scoring a touchdown against the Tampa Bay Buccaneers during the second half of an NFL football game, Sunday, Nov. 16, 2025, in Orchard Park, N.Y. AP Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

The Bills roll into Houston as 5.5-point road favorites , but this matchup looks far tighter than that number suggests.

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Buffalo is coming off a fireworks show against Tampa Bay, yet it still hasn’t lined up against a defense with Houston’s pedigree, especially on a short week.

With the Texans

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